716 AP2 Vrs CB's

If it was the club, everyone would have the same problem. I too seem to struggle more with clubs with more offset. If CB’s work for you and it’s what you have trained your swing to work with, stick to it. If not, expect to find the answer in the dirt.

Is it consistently missing the same side? Maybe just alignment issue due to different look?

I don't know, but I just switched to 718 AP2s from 712 AP1s. And even though I just started golfing in February, I'm striking the smaller club head so much better than those big fat AP1 game improvements. I'm getting longer distance, likely due to much lower ball flight. I was skying the AP1s.